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Trial Watch: Therapeutic vaccines in metastatic renal cell carcinoma. Curr Top Med Chem. Lung Cancer. One method to boost antigen presentation is to introduce specific point mutations in the sequence of the antigenic epitope, resulting in improved binding to MHC Class I molecules or the T-cell receptor TCR. One thing for sure, she wanted as much of this feeling as she could get. Discovery of mesothelin and exploiting it as a target for immunotherapy. Close Working

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